更多关于已证实属于一般公认为安全（GRAS）的可直接加入食品中的物质种类，请点击美国FDA 21 CFR 第184部分已证实属于一般公认为安全（GRAS）的可直接加入食品中的物质种类汇总
§ 184.1318 Glucono delta-lactone.
（a） Glucono delta-lactone （C6H10O6, CAS Reg. No. 90–80–2）, also called D -gluconic acid delta-lactone or D -glucono-1,5-lactone, is the cyclic 1,5-intramolecular ester of D -gluconic acid. It is prepared by direct crystallization from the aqueous solution of gluconic acid. Gluconic acid may be produced by the oxidation of D -glucose with bromine water, by the oxidation of D -glucose by microorganisms that are nonpathogenic and nontoxicogenic to man or other animals, or by the oxidation of D -glucose with enzymes derived from these microorganisms.
（b） The ingredient meets the specifications of the Food Chemicals Codex, 3d Ed. （1981）, p. 134, which is incorporated by reference. Copies are available from the National Academy Press, 2101 Constitution Ave. NW., Washington, DC 20418, or available for inspection at the National Archives and Records Administration （NARA）. For information on the availability of this material at NARA, call 202–741–6030, or go to: http://www.archives.gov/federal_register/code_of_federal_regulations/ibr_locations.html.
（c） In accordance with §184.1（b）（1）, the ingredient is used in food with no limitation other than current good manufacturing practice. The affirmation of this ingredient as generally recognized as safe （GRAS） as a direct human food ingredient is based upon the following current good manufacturing practice conditions of use:
（1） The ingredient is used as a curing and pickling agent as defined in §170.3（o）（5） of this chapter, leavening agent as defined in §170.3（o）（17） of this chapter; pH control agent as defined in §170.3（o）（23） of this chapter; and sequestrant as defined in §170.3（o）（26） of this chapter.
（2） The ingredient is used at levels not to exceed current good manufacturing practice.
（d） Prior sanctions for this ingredient different from the uses established in this section do not exist or have been waived.
[51 FR 33896, Sept. 24, 1986]
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